How to use Clexane correctly?

How to use Clexane correctly?

What is Clexane?

Clexane is just one of many drugs used in medicine, including obstetrics, gynecology, and reproductive medicine, to thin the blood. For example, Fraxiparin, Fragmin and others have the same effect. These are all low molecular weight heparins. Their feature is to resist the formation of blood clots, thanks to which it is possible to save the lives of many people (including with today’s dangerous viral infection), as well as to preserve the pregnancy and help avoid complications during therapy with hormonal drugs.

Disorder of blood clotting underlies many pathological processes. I will not describe in detail the entire complex mechanism of blood clots formation, I will only say that this is the most common cause of early pregnancy loss. The sources of such complications can be both severe preeclampsia and the most dangerous condition – disseminated intravascular coagulation, that is, a condition when, due to the massive formation of blood clots, the blood coagulation system “breaks down” and can no longer work, after which bleeding is practically impossible to stop.

Adequate and timely use of anticoagulants saves from all these problems.

When we apply them

  1. After the transfer against the background of ovulation stimulation to prevent ovarian hyperstimulation syndrome (if there is a risk of developing such a complication, and for  some reason the transfer could not be postponed);
  2. In the case of preparing the endometrium for pregnancy against the background of the use of hormone replacement therapy with high doses of estrogens (they have a rather dangerous side effect – the risk of blood clots);
  3. In case of recurrent miscarriage (loss from 2 pregnancies), especially if the examination reveals antibodies to phospholipids, lupus anticoagulant, an increased level of d-Dimer, Leiden mutation and other factors predisposing to hemostasis disorder.
  4. During pregnancy, the level of d-dimer, hemostasiogram and other factors are necessarily monitored, on the basis of which a decision is made to continue taking heparin drugs (sometimes they have to be taken until the very birth).

When we cancel them

  1. With bloody discharge from the genital tract;
  2. Before any surgery;
  3. Before a planned caesarean section or childbirth, at least 2 days to avoid bleeding.

I know perfectly well how literate and well-read you are. You have heard almost in detail about thrombophilia, Leiden mutations, an increase in the level of d-Dimer and other (rather complicated!) Things when you have to resort to interfering with the hemostasis process. And many girls, coming to the reception, themselves ask to appoint Clexan, having read on the forums how useful and important it is. And often they are supported in this by doctors from antenatal clinics, who prescribe anticoagulants, monitoring the level of d-dimer during pregnancy, while frightening already intimidated women with possible complications. But here I would like to slow down your zeal a little. Despite those words of praise for the drug that I wrote above, I ask you not to use it without a doctor’s prescription and not to increase the recommended dosage!

Once I happened to attend a very instructive lecture by a hematologist, candidate of medical sciences, Maria Alekseevna Vinogradova. Then she shared several cases from her practice, when unjustified intake of heparins only on the basis of a blood test for thrombophilia and monitoring of the level of d-Dimer led to severe complications during pregnancy: the formation of pneumonia due to intrapulmonary bleeding, nose and ear bleeding. All this was eliminated by canceling unnecessary drugs. But, according to her, the struggle with similar situations in her practice is ongoing.

It is always important to remember that any coin has two sides. The drug gives a beneficial effect only when the dosage is correctly selected, and adequate monitoring of its effectiveness is carried out. There is no need to use heparin drugs as preventive therapy (several months before the protocol, for example). I also had to deal with such cases when a woman used Clexane “to prepare for pregnancy” due to the fact that she had several forms of so-called thrombophilia. Heparins only work while you inject them. These drugs do not have a cumulative effect, therefore, such preparation will not lead to anything other than the loss of funds and provoking complications.


When to take Clexane?

The dosage of the drugs is selected individually, based on the patient’s weight and under the strict control of the hemostasiogram. The duration of taking the drug is also determined individually, depending on the indications – from several days to several months.

And one more thing that is important to know: heparin preparations are included in the list of compulsory medical insurance and are issued in the IVF program for compulsory medical insurance free of charge (although the number of ampoules in this case is limited).


This article contains information only. Please always consult your doctor before taking this medicine.


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