Mirtazapine for sleep


Sleep is the foundation of health. Sufficient sleep helps in maintaining a Healthy Lifestyle. This is from ZopicloneForUk; we cover detailed information on mirtazapine for sleep. Furthermore, help or to buy zopiclone visit there.

A hectic schedule and busy lifestyle results in sleeplessness. It’s hard for a person to fall asleep, and there is a rise in sleep disorders. Such problems are observed in every age group, and they experience them at least once a month.

Sleep is the best medication, but people are turning to medicines with the hope of treating sleep disorders (insomnia). Mirtazapine is one such medication that helps in treating insomnia. There have been indications that Mirtazapine shows positive results for sleep disorders after a prolonged consumption period. 

Does Mirtazapine Help You Sleep?

Mirtazapine is a prescribed medication approved by the FDA for major depressive disorder(MDD). It is sold under the brand name Remeron. It is a typical antidepressant used to treat symptoms of depression, stress, mental illness, mood disorders, etc.

Mirtazapine is not an asleep medication but works as a sleeping aid for people suffering from sleep disorders.

The sedative effects of Mirtazapine help people suffering from anxiety and depression to fall asleep and improve the quality and quantity of sleep. The off-label indication for Mirtazapine for rest is rarely prescribed for insomnia.

How Does Mirtazapine Work On Your Sleep System?

Mirtazapine is an antidepressant that works on the central nervous system. It increases the concentration of neurotransmitters(chemical messengers) serotonin and noradrenaline in the brain.

Neurotransmitters help improve the mood and boost energy levels in patients with depression. The secondary work of every antidepressant is to make you feel drowsy and sleep fast. The increase in sleep helps you feel the effect on overall mood and reduces the level of stress and anxiety. Sleeping can be helpful for an individual to get in a present and efficient state of mind.

Mirtazapine Has a Possible Side Effect

Short-term side effects of Mirtazapine are 

  • Weight gain can be a total drastic change in your body weight or might affect the muscle mass depending on the individual.
  • Daytime drowsiness is a common side effect of any sleeping medication on the body. You might feel lethargic and might feel less enthusiastic.
  • Dizziness can be a prime effect of being uninterested in the rest of the day’s activities.
  • Dry mouth is due to unaccounted hours of sleep. As we sleep more, our body gets dehydrated.
  • Constipation can happen due to less intake of water and medications’ effect on the digestive system.
  • Strange dreams and sleep disorders(restless legs syndrome or periodic limb movement).

Long-term side effects of Mirtazapine are 

  • Abnormal thoughts can be due to the medication affecting the underlying areas of the brain.
  • The bitter taste is one of the prime side effects of continuous medication consumption affecting the taste buds.
  • Skin rash is observed depending on the skin type of an individual.
  • Swelling can be seen on certain parts of your body depending on the intensity of the medication affecting your CNS.
  • Headaches are common if used for an extended period of time.
  • Nausea and vomiting are felt if the medication is used in excessive amounts. 
  • Agitation can be observed in individuals as a long-term side effect.

Let Us Get Information About Mirtazapine Dosage for Sleep

The available form of Mirtazapine is 15mg,30mg,45mg for standard tablets, dispersible tablets, and a liquid solution is 15ml.

Consult a doctor before using Mirtazapine. For sleep problems, the low dosage is 15 mg, and you can consume it once a day during bedtime without food.

The dosage amount will increase gradually after some time, to nearly 45mg. The off-label low dose is 7.5mg, effective in many people.

Mirtazapine and Sleep

The human sleep cycle does not get affected easily. Different drugs work differently on the sleep disorders a person faces in terms of medications for sleep.

In the case of Mirtazapine, it creates an enthusing sleep cycle to get better results. Mirtazapine doesn’t affect you immediately. You will notice sleep improvement within a few weeks or 1 to 2 weeks.

You will feel better, and the results will be beneficial within 4 to 6 weeks. 

Best Time to Take Mirtazapine for Sleep

As many people have observed that their body reacts differently while consuming Mirtazapine, there is no recommended time. People facing severe sleep disorders consume as per the directions of the consultation. Change the time through proper guidance if you feel no difference, irrespective of the time consumed. Most individuals have thought that the best time for finishing Mirtazapine is usually during bedtime for better sleep.


Everyone loves peaceful sleep, but if sleeping is difficult, we are irritated and frustrated and tend to seek help. Mirtazapine works as a sedative agent, which makes you feel drowsy. Sleeping disorders are commonly observed in people suffering from anxiety and depression. You can face it anytime, and people recover from it through help and support. The right amount of sleep helps you have a healthy life, and proper medication can help you get back your sleep on track.


  1. Gandotra, K., Chen, P., Jaskiw, G.E., Konicki, P.E. and Strohl, K.P., 2018. Effective treatment of insomnia with mirtazapine attenuates concomitant suicidal ideation. J. Clin. Sleep Med., 14(5), pp.901-902.
  2. Winokur A, Sateia MJ, Hayes JB, Bayles-Dazet W, MacDonald MM, Gary KA. 2000. Acute effects of mirtazapine on sleep continuity and sleep architecture in depressed patients: a pilot study. Biol. Psych. Jul 1;48(1):75-8
  3. Leonard, S.D. and Arun Karlamangla, A., 2015. Dose-Dependent Sedating and Stimulating Effects of Mirtazapine. Proc. UCLA Health, 19: 1– 2.
  4. Kolla, B.P., Mansukhani, M.P. and Bostwick, J.M., 2018. The influence of antidepressants on restless legs syndrome and periodic limb movements: A systematic review. Sleep med. rev., 38, pp.131-140.
  5. Hennings JM, Heel S, Lechner K, Uhr M, Dose T, Schaaf L, Holsboer F, Lucae S, Fulda S, Kloiber S., 2019. Effect of mirtazapine on metabolism and energy substrate partitioning in healthy men. JCI Insight. Jan 10;4(1). pii: 123786.
  6. Ruigt, G.S.F., Kemp, B., Groenhout, C.M. and Kamphuisen, H.A.C., 1990. Effect of the antidepressant Org 3770 on human sleep. Eur. J Clin. Pharmacol., 38(6), pp.551-554.
  7. Aslan, S., Isik, E. and Cosar, B., 2002. The effects of mirtazapine on sleep: a placebo controlled, double-blind study in young healthy volunteers. Sleep, 25(6), pp.666-668.
  8. Karsten, J., Hagenauw, L.A., Kamphuis, J. and Lancel, M., 2017. Low doses of mirtazapine or quetiapine for transient insomnia: a randomised, double-blind, cross-over, placebo-controlled trial. J. Psychopharmacol., 31(3), pp.327-337.
  9. Savarese M, Carnicelli M, Cardinali V, Mogavero MP, Federico F., 2015. Subjective hypnotic efficacy of Trazodone and Mirtazapine in patients with chronic insomnia: a retrospective, comparative study. Arch Ital. Biol. Jun-Sep;153(2-3):231-8.
  10. Kamphuis, J., Taxis, K., Schuiling-Veninga, C.C., Bruggeman, R. and Lancel, M., 2015. Off-label prescriptions of low-dose quetiapine and mirtazapine for insomnia in The Netherlands. J. Clin. Psychopharmacol., 35(4), pp.468-470.

Leave a Comment

Your email address will not be published.