Sumatriptan-Mepha Solution Injection

Sumatriptan-Mepha Solution Injection

What is it and how do I use it?

Sumatriptan-Mepha solution for injection is used in the acute treatment of migraine attacks.

Sumatriptan Injection is also intended for the treatment of cluster headache (cluster migraine: unilateral pain, intense, of short duration, appearing in the form of seizures).

It is believed that migraine pain is caused by painful dilation and inflammation of blood vessels in the head. Sumatriptan-Mepha relieves migraine pain by narrowing the dilated blood vessels.

Sumatriptan-Mepha should not be used for the prevention (prophylaxis) of migraine or cluster headache.

Sumatriptan-Mepha solution for injection should only be used on prescription from a doctor.

What should you consider before using it?

Sumatriptan-Mepha solution for injection should not be used in case of hypersensitivity to any component of the drug, untreated hypertension, a history of myocardial infarction, kidney damage or serious liver disease, known circulation disorders in the heart (angina pectoris), brain and extremities.

Sumatriptan-Mepha solution for injection should not be used at the same time as the following medicines:

  • MAO inhibitors (certain antidepressants or products for Parkinson’s disease). Treatment with Sumatriptan-Mepha should not be started until 2 weeks after stopping the MAO inhibitor.
  • Migraine medications containing ergotamine or its derivatives (such as dihydroergotamine or methysergide, for example). During the 24 hours before and 6 hours after the administration of Sumatriptan-Mepha, products containing ergotamine should not be taken.

In rare cases, an effect called “serotonin syndrome” may occur when triptans, such as Sumatriptan-Mepha, are given together with other medicines with serotonergic effects. These include: certain antidepressants (eg medicines called selective serotonin reuptake inhibitors or selective serotonin / norepinephrine reuptake inhibitors, MAO inhibitors, L-tryptophan, lithium, tricyclic antidepressants, etc.). Tell your doctor if you are being treated with these medicines. “Serotonin syndrome” may include the following symptoms: increased excitability of intrinsic muscle reflexes, convulsive muscle movements, tremors, restlessness, anxiety, hallucinations, irritability leading to confusion and loss of consciousness, rapid heartbeat, fluctuations in blood pressure, nausea, vomiting, fever and diarrhea. Tell your doctor if any of these symptoms appear in you after taking Sumatriptan injection.

Simultaneous administration of Sumatriptan-Mepha and other specific migraine medications (called triptans) is not recommended.

Please tell your doctor or pharmacist if you suffer from any other disease such as high blood pressure or cardiovascular disease, blood circulation disorders, liver or kidney disease or epilepsy, if you are allergic or if you are already taking other medicines for internal or external use (even self-medication)!

If you are being treated with medicines called beta blockers which can also be used for migraine prophylaxis, your doctor will prescribe Sumatriptan-Mepha especially carefully.

Headaches may get worse if you use Sumatriptan-Mepha too often. In this case, your doctor may stop treatment with Sumatriptan injection.

This medicine may affect reactions, the ability to drive, and the ability to use tools or machines!

Drowsiness may also occur following migraine or its treatment with Sumatriptan-Mepha. Caution should therefore be exercised if you must drive a vehicle or use machines during treatment.

If you are pregnant or wish to become pregnant, Sumatriptan-Mepha solution for injection should not be used unless clearly necessary.

Small amounts of the active substance in Sumatriptan-Mepha pass into breast milk. To protect the infant, discontinue breast-feeding for 12 hours after administration of Sumatriptan-Mepha solution for injection and use a breast pump.

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How to use Sumatriptan injection?

Sumatriptan-Mepha solution for injection can only be used with Sumatriptan-Mepha Pen. Carefully read the instructions for use enclosed with this package before starting the treatment.

Unless the doctor advises otherwise, the dosage is as follows:

Adults and adolescents over 18

Migraine: Apply 1 injection of 6 mg when the first signs of migraine pain appear, or even after the attack has started. It is only if the migraine symptoms reappear secondarily, that it is possible to apply 1 more injection within 24 hours, provided that you wait at least 1 hour after the first injection. The maximum dose per 24 hours is 2 injections (2 × 6 mg). In these 24 hours, in addition to the two injections, do not take Lactab Sumatriptan-Mepha or Lactab Sumatriptan-Mepha T resp. do not use any other medicine containing sumatriptan.

The second injection may however be replaced by a single dose of another dosage form containing sumatriptan used at the recommended dosage.

If the first injection has not been effective, no further injections of Sumatriptan-Mepha should be given during the same migraine attack, but the usual painkillers should be used for the remainder of the treatment, as long as those – these do not contain ergotamine or dihydroergotamine. Sumatriptan-Mepha solution for injection can again be used for subsequent migraine attacks.

Cluster Headache: 1 injection may be given for each attack. The maximum dose per 24 hours is 2 injections (2 × 6 mg). The administration of the second injection will take place no earlier than 1 hour after the first injection.

Children and adolescents under 18 and adults over 65

Sumatriptan-Mepha solution for injection should not be given to children and adolescents under 18 years of age and adults over 65 years of age, as there is still too little experience.

Do not change the prescribed dosage on your own. Talk to your doctor or pharmacist if you think that the effectiveness of the drug is too weak or on the contrary too strong.

What are the possible side effects ?

The use of Sumatriptan injection may cause the following side effects:

Very common (in more than 1 in 10 people treated): transient pain, stinging, burning, swelling, redness, bruising or bleeding at the injection site.

Common (less than 1 in 10 people treated but more than 1 in 100): dizziness, lightheadedness, tingling, transient increase in blood pressure, shortness of breath, facial flushing, nausea, vomiting, pain, weakness, fatigue, feeling of heat, cold, pressure, tightness and heaviness in different parts of the body (including chest and throat).

Very rare (in less than 1 in 10,000 people treated, including isolated cases): hypersensitivity reactions of any severity (e.g. rash, attacks of choking up to shock which can be threatening). life), seizures, tremors, dystonia (slow involuntary increase in muscle tension associated with abnormal postures and movements), involuntary oscillatory movements of the eyeballs (nystagmus), visual field deficiencies (scotomas), visual disturbances such as as flickering, doubling, reduced visual acuity or loss of vision (but apart from that, visual disturbances can also appear as concomitant symptoms of the migraine itself), slowing or accelerating of the heartbeat, palpitations, heart rhythm disturbances,disturbances in cardiac irrigation, coronary vessel spasms, myocardial infarction, drop in blood pressure, insufficient irrigation of the limbs (Raynaud’s syndrome), inflammation of a section of the large intestine due to insufficient irrigation (ischemic colitis ), minimal changes in liver values.

If you have blood pressure problems or chest pain, please contact your doctor immediately.

If you notice any side effects which are not mentioned in this leaflet, please inform your doctor or pharmacist.

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How should the product be stored?

  • Sumatriptan-Mepha solution for injection should not be stored above 30 ° C. Keep away from light and out of the reach of children.
  • Do not freeze.
  • The medicine should not be used after the date shown after the word “EXP” on the container.

For more information, consult your doctor or pharmacist, who have detailed information for professionals.

More information

1 cartridge of 0.5 ml contains 6 mg sumatriptan as active substance as well as sodium chloride and water for injections as excipients.

Warnings:

This article contains information only. Please always consult your doctor before taking this medicine.

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