What are monogenic disorders?

monogenic disorders

Monozygotic twins have been described as having two identical physical bodies but two different souls. Such disorders are easily pre-identifiable using the PCR technique.

But that is not the case, let’s explore monogenetic disorders. 

Monozygotic babies possess a unique genetic inheritance and genetic structure of, monozygotic twins tend to have different mentalities. There are studies on the possibility of intelligence differences between monozygotic twins but with current data there does not seem to be enough to quantify the differences in intelligence of monozygotic twins.

I have a daughter named L’Sophia, a twin with the same family as me, but because of genetic differences, she is mentally much more mature than my daughter and tries to emulate my example. When we first had L’Sophia, I let her do what she wanted. The differences between twins are not often obvious to everyone. In fact, when I worked my way up the ladder at Boy George Mobile Fun Space Shoppes, I knew my daughter didn’t like certain things but I wasn’t really sure she was smarter than me.

Since there isn’t a lot of genetic testing done for twins, and developmental differences between twins are natural, the differences in intelligence seem much harder to explain as a cause for monozygotic twins. If you’re a twin and ever wondered about a more significant difference in mental health between siblings or identical twins, do some more research. You might find out you’re not as different as you might think.

Having twins doesn’t automatically mean you will have an opposite twin or that you don’t have your biological parents. Have you heard the term?

The term “monozygotic twins” means the two twins share the same chromosomal triples (dual XYY).

There are some rare conditions that indicate some genetic variance in siblings, but so far there are no conclusive studies proving genetic differences to determine which twin is the more intelligent of twins.

When twins are diagnosed with monozygotic twins, it is seen through genetic testing. Be sure you can find a geneticist with experience in twins who has been trained to examine twins born with these different cultural, geographical, psychological, and medical issues.

Causes of Monozygotic Twins

There are many causes of monozygotic twins. Some of these causes are biological and others are psychological.

Genetic Factors

In some cases, twins tend to suffer from a metabolic or genetic disorder that makes it difficult for them to bond with each other.

Medical Factors

There are several medical factors that could cause monozygotic babies to have a negative impact on each other.

Premature Infancy

For monozygotic identical babies, they can suffer from a low birth weight and die if they are born prematurely.


For twins born with immune system issues, they tend to have an increased rate of infections that can be triggered by bacterial mutations in the fetus. Some allergies are hereditary and others are not. One significant epigenetic change can be associated with an increased incidence of allergies.

Brain Plasticity

There are genetic factors in twin development that can change the functioning of the brain’s ability to reorganize and develop.

Human trait-specific brain factors are more likely to predict schizophrenia, bipolar disorder, attention issues, hypochondriacal symptoms, depression, anxiety, obsessive compulsive disorder, and obsessive-compulsive personalities.

Reactive Hypertension

For monozygotic twins, some of these issues can include hyperthyroidism, which may result in low energy levels, or diabetes, which may cause severe weight gain.

Mayo’s Neurolink study says that mitochondrial differences are more likely in the first and late stages of a monozygotic twins’ development. These researchers concluded that this proves the stress hormones are programmed in the brain in order to produce young children.

Social Problems

As children and adolescents, twins have a wide variety of social issues related to stress, eating disorders, lack of sleep, anxiety, some children show signs of anxiety and depression in people who have had long-term childhood illnesses.

Occurrence of Melanoma

There are many genetic factors that are associated with an increased risk of a young person developing melanoma.


Monogenic Disorders are a result of single gene sequence deviation and they are commonly identified by analyzing inheritance or genetic patterns. Monogenetic traits can be Mendelian as well as non-Mendelian genetic patterns such as sex-linked and mitochondrial genetic expression. Some other elements deviate clinical impacts for example, variable penetrance and expressivity.

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